Our tumour studies are split into 7 categories:

• Glioblastoma
• Other glial tumour
• Meningioma
• Metastatic tumour
• Paediatric
• Pituitary
• Other

Please visit each category below to view the individual lay summaries.

Other glial tumour

• Investigating the spatial omics of G34R/V gliomas
  Brain UK study ref: 24/015, Lay summary, Project status: Active… Read more: Investigating the spatial omics of G34R/V gliomas
• Integrated molecular profiling of paediatric-type diffuse high-grade glial tumours
  Brain UK study ref: 24/014, Lay summary, Project status: Active… Read more: Integrated molecular profiling of paediatric-type diffuse high-grade glial tumours
• IDH-mutant diffuse glioma with primitive neuronal component
  Brain UK study ref: 24/012, Lay summary, Project status: Active… Read more: IDH-mutant diffuse glioma with primitive neuronal component
• Investigating progression and transformation of IDH1/2 mutant hemispheric astrocytomas in adults
  Brain UK study ref: 24/010, Lay summary, Project status: Active… Read more: Investigating progression and transformation of IDH1/2 mutant hemispheric astrocytomas in adults
• P16 expression as a surrogate marker for homozygous deletion of CDKN2A in IDH-mutant astrocytomas
  Brain UK study ref: 24/004, Lay summary, Project status: Active… Read more: P16 expression as a surrogate marker for homozygous deletion of CDKN2A in IDH-mutant astrocytomas
• Characterisation of rare neuronal and glial tumour types to increase diagnostic accuracy, identify treatment targets and improve prognostication
  Brain UK study ref: 24/002, Lay summary, Project status: Active… Read more: Characterisation of rare neuronal and glial tumour types to increase diagnostic accuracy, identify treatment targets and improve prognostication
• Understanding microenvironmental determinants of glioblastoma invasion
  Brain UK study ref: 23/023, Lay summary, Project status: Active… Read more: Understanding microenvironmental determinants of glioblastoma invasion
• Epidemiologic, Histologic, and Molecular Features of Methylation Class Pleomorphic Xanthoastrocytoma
  Brain UK study ref: 23/015, Lay summary, Project status: Active… Read more: Epidemiologic, Histologic, and Molecular Features of Methylation Class Pleomorphic Xanthoastrocytoma
• Investigating the expression of BACE1 in human astrocytoma
  Brain UK study ref: 23/001, Lay summary, Project status: Active… Read more: Investigating the expression of BACE1 in human astrocytoma
• Multi-modal computational interrogation of the molecular-morphological intersection in brain tumours
  Brain UK study ref: 22/021, Lay summary, Project status: Active… Read more: Multi-modal computational interrogation of the molecular-morphological intersection in brain tumours
• Microglia activation in IDH1 WT glioma is essential for peripheral macrophage recruitment
  Brain UK study ref: 22/017, Lay summary, Project status: Active… Read more: Microglia activation in IDH1 WT glioma is essential for peripheral macrophage recruitment
• Retrospective and prospective analysis of digital images of histology slides of brain tumours using machine learning and deep learning to predict/identify molecular properties
  Brain UK study ref: 22/015, Lay summary, Project status: Active… Read more: Retrospective and prospective analysis of digital images of histology slides of brain tumours using machine learning and deep learning to predict/identify molecular properties
• Artificial intelligence-based reconstruction of the WHO 2021 diagnostic algorithm for adult-type diffuse gliomas
  Brain UK study ref: 22/011, Lay summary, Project status: Active… Read more: Artificial intelligence-based reconstruction of the WHO 2021 diagnostic algorithm for adult-type diffuse gliomas
• Role of microglial subtypes in neurodevelopmental brain diseases
  Brain UK study ref: 22/003, Lay summary, Project status: Active… Read more: Role of microglial subtypes in neurodevelopmental brain diseases
• Classification and characterisation of spinal glial tumours
  Brain UK study ref: 21/019, Lay summary, Project status: Active… Read more: Classification and characterisation of spinal glial tumours
• Immunohistochemical study of H3.3 K27M expression in canine glioma: a potential model for human diffuse midline glioma
  Brain UK study ref: 21/011, Lay summary, Project status: Closed… Read more: Immunohistochemical study of H3.3 K27M expression in canine glioma: a potential model for human diffuse midline glioma
• Investigating regional heterogeneity and progression-associated markers in oligodendrogliomas
  Brain UK study ref: 21/007, Lay summary, Project status: Active… Read more: Investigating regional heterogeneity and progression-associated markers in oligodendrogliomas
• Investigating a Surrogate Marker to Distinguish Astrocytomas and Oligodendrogliomas
  Brain UK study ref: 21/002, Lay summary, Project status: Active… Read more: Investigating a Surrogate Marker to Distinguish Astrocytomas and Oligodendrogliomas
• Bithalamic Gliomas in children and adolescents: Clinical, radiological, histopathological, (epi-)genomic, molecular and survival characteristics
  Brain UK study ref: 20/016, Lay summary, Project status: Closed… Read more: Bithalamic Gliomas in children and adolescents: Clinical, radiological, histopathological, (epi-)genomic, molecular and survival characteristics
• Relating neuropathological features to clinical outcome in spinal ependymomas
  Brain UK study ref: 20/001, Lay summary, Project status: Active… Read more: Relating neuropathological features to clinical outcome in spinal ependymomas
• Investigating a role for dystrophin in survival outcomes of low grade glioma patients: A pilot study
  Brain UK study ref: 19/010, Lay summary, Project status: Active… Read more: Investigating a role for dystrophin in survival outcomes of low grade glioma patients: A pilot study
• Molecular analyses of glial and glioneuronal tumours by DNA methylation profiling and next generation sequencing (NGS)
  Brain UK study ref: 19/001, Lay summary, Project status: Active… Read more: Molecular analyses of glial and glioneuronal tumours by DNA methylation profiling and next generation sequencing (NGS)
• An Investigation of the Clinical Utility of Genetic and Epigenetic Profiling in Glioma
  Brain UK study ref: 18/005, Lay summary, Project status: Closed… Read more: An Investigation of the Clinical Utility of Genetic and Epigenetic Profiling in Glioma
• Identification of novel therapeutic targets and/or predictive biomarkers in brain gliomas
  Brain UK study ref: 17/002, Lay summary, Project status: Closed… Read more: Identification of novel therapeutic targets and/or predictive biomarkers in brain gliomas
• The development of a molecular methodology for improved detection of Isocitrate Dehydrogenase mutations in diffuse gliomas
  Brain UK study ref: 16/015, Lay summary, Project status: Closed… Read more: The development of a molecular methodology for improved detection of Isocitrate Dehydrogenase mutations in diffuse gliomas
• Multi-platform analysis of TSC Subependymal Giant Cell Astrocytoma (SEGA) to identify novel therapeutic approaches
  Brain UK study ref: 16/002, Lay summary, Project status: Active… Read more: Multi-platform analysis of TSC Subependymal Giant Cell Astrocytoma (SEGA) to identify novel therapeutic approaches
• Identifying Circulating Tumour Cells in the Blood: An Analysis of their Diagnostic and Prognostic Significance in Correlation with Biopsy Findings
  Brain UK study ref: 15/006, Lay summary, Project status: Active… Read more: Identifying Circulating Tumour Cells in the Blood: An Analysis of their Diagnostic and Prognostic Significance in Correlation with Biopsy Findings
• An analysis of PPAR expression in human gliomas: Its use as a novel diagnostic, prognostic and predictive biomarker
  Brain UK study ref: 14/008, Lay summary, Project status: Closed… Read more: An analysis of PPAR expression in human gliomas: Its use as a novel diagnostic, prognostic and predictive biomarker
• Pilot study: Expression analysis of candidate transcripts potentially involved in human brain tumourigenesis
  Brain UK study ref: 14/004, Lay summary, Project status: Active… Read more: Pilot study: Expression analysis of candidate transcripts potentially involved in human brain tumourigenesis
• Investigating inflammation of the normal appearing brain in patients with low-grade glioma
  Brain UK study ref: 13/002, Lay summary, Project status: Closed… Read more: Investigating inflammation of the normal appearing brain in patients with low-grade glioma
• Are neurodegenerative diseases and gliomas inverse comorbidities?
  Brain UK study ref: 13/001, Lay summary, Project status: Closed… Read more: Are neurodegenerative diseases and gliomas inverse comorbidities?

Metastatic tumour

• Understanding the role of B7-H3 in melanoma brain metastases
  Brain UK study ref: 24/018, Lay summary, Project status: Active… Read more: Understanding the role of B7-H3 in melanoma brain metastases
• The role of amyloid-precursor protein processing (APP) in breast cancer; lessons learnt from Alzheimer’s disease
  Brain UK study ref: 23/010, Lay summary, Project status: Active… Read more: The role of amyloid-precursor protein processing (APP) in breast cancer; lessons learnt from Alzheimer’s disease
• Defining the role of STAT3 in astrocyte adaptation to hypoxia as therapeutic target in brain cancers
  Brain UK study ref: 21/012, Lay summary, Project status: Active… Read more: Defining the role of STAT3 in astrocyte adaptation to hypoxia as therapeutic target in brain cancers
• Characterisation of the epigenetic changes induced by targeted radiotherapy for brain metastases
  Brain UK study ref: 20/005, Lay summary, Project status: Active… Read more: Characterisation of the epigenetic changes induced by targeted radiotherapy for brain metastases
• Defining changes in the tumour microenvironment of melanoma brain metastases following anti-PD-1 and anti-CTLA-4 antibody therapy
  Brain UK study ref: 17/012, Lay summary, Project status: Active… Read more: Defining changes in the tumour microenvironment of melanoma brain metastases following anti-PD-1 and anti-CTLA-4 antibody therapy
• Investigation of the role of the c-MET proto-oncogene and the PI3K/AKT/mTOR pathway in brain metastasis
  Brain UK study ref: 16/001, Lay summary, Project status: Active… Read more: Investigation of the role of the c-MET proto-oncogene and the PI3K/AKT/mTOR pathway in brain metastasis
• Identifying Circulating Tumour Cells in the Blood: An Analysis of their Diagnostic and Prognostic Significance in Correlation with Biopsy Findings
  Brain UK study ref: 15/006, Lay summary, Project status: Active… Read more: Identifying Circulating Tumour Cells in the Blood: An Analysis of their Diagnostic and Prognostic Significance in Correlation with Biopsy Findings

Pituitary

• Pathological and molecular stratification of ACTH-secreting pituitary tumours to predict recurrence after bilateral adrenalectomy
  Brain UK study ref: 20/010, Lay summary, Project status: Active… Read more: Pathological and molecular stratification of ACTH-secreting pituitary tumours to predict recurrence after bilateral adrenalectomy
• Analysis of senescence in pituitary adenomas
  Brain UK study ref: 19/013, Lay summary, Project status: Active… Read more: Analysis of senescence in pituitary adenomas
• Predicting recurrence/regrowth of non-functioning pituitary adenoma by a combination of patients’ clinical, biochemical, radiological and immunohistochemical outcomes
  Brain UK study ref: 19/003, Lay summary, Project status: Closed… Read more: Predicting recurrence/regrowth of non-functioning pituitary adenoma by a combination of patients’ clinical, biochemical, radiological and immunohistochemical outcomes
• Molecular neuropathology of posterior pituitary/TTF-1-positive neoplasms
  Brain UK study ref: 15/016, Lay summary, Project status: Closed… Read more: Molecular neuropathology of posterior pituitary/TTF-1-positive neoplasms