
Recently approved lay summaries
- BRAIN UK Ref: 25/021 – Advancing knowledge of brain development: The key to understanding brain injury mechanisms in preterm infants
Babies born too early (preterm), especially before 28 weeks of pregnancy, are at risk of facing… Read more - BRAIN UK Ref: 25/019 – Multimodal approach to investigate pathomechanisms and biomarkers for early diagnosis of Rasmussen Encephalitis (RE)
Rasmussen Encephalitis (RE) is a rare and devastating brain disease affecting children, leading to uncontrollable seizures, one-sided paralysis, and loss of speech or learning ability…Read more - BRAIN UK Ref: 25/018 – Analysing mtDNA large scale rearrangements in patient and control muscle tissue (a substudy of the International Centre for Genomic Medicine in Neuromuscular Disease)
We’re looking at why some people get genetic diseases that affect their nerves and muscles. We’re focusing on tiny parts of cells called… Read more - BRAIN UK Ref: 25/017 -Examining immune-tumour interactions in diffuse midline glioma
Paediatric diffuse midline glioma (DMG) is one of the most aggressive childhood brain cancers, characterised by a mutation called H3K27M. These tumours grow in the… Read more - BRAIN UK Ref: 25/015 – Investigating inflammatory pathways in mitochondrial disease
Mitochondrial diseases are rare disorders that affect the energy-generating “batteries” of the cell. Patients may suffer from cognitive decline, movement disorder, seizures. There are no therapies for mitochondrial diseases. Read more - Brain UK Ref: 25/014 – Identifying patient prognostic biomarkers of glioma connectivity
Gliomas, like glioblastoma (GBM) and diffuse midline glioma (DMG), are common yet aggressive brain tumours with no effective cure. Recent research has shown… Read more - BRAIN UK Ref: 25/013 – Do AN1792 trial patients still show ASC positive cores of former Abeta plaques?
Alzheimer’s disease (AD) is the most common form of dementia, mainly affecting older people. As people in Western countries live longer, more AD cases are… Read more - BRAIN UK Ref: 25/012 – Understanding the role of the extracellular matrix in ependymoma
Cancer in children is caused by cells growing out of control. These cancer cells grow faster than normal cells, invade nearby tissues, and sometimes enter blood vessels. Read more - BRAIN UK Ref: 25/011 – Transcriptomics analysis of cerebral amyloid angiopathy-related inflammation
Aduhelm is a new treatment for Alzheimer’s disease that has been approved in the United States. This treatment involves immunotherapy against a protein that… Read more - BRAIN UK Ref: 25/010 – Molecular analysis of brains of patients administered the AN1792 (Aβ42) vaccine
Alzheimer’s disease is the commonest cause of dementia in later life, responsible for two thirds of cases. It affects about 5% of people over 65 years of age… Read more
