Recently approved lay summaries
- BRAIN UK Ref: 26/011 – Uncovering the mechanisms behind peripheral macrophage recruitment in Diffuse Midline Glioma
Diffuse midline glioma is a fast-growing brain tumour that mostly affects children. There are very few effective treatments, so we urgently need to understand how these tumours interact with the healthy cells around them… Read more - BRAIN UK Ref: 26/010 – Clinical and molecular characteristics associated with prognosis and treatment response in meningiomas – a retrospective exploratory analysisMeningiomas are tumours that develop in the protective layers around the brain. Some grow back after treatment. This study aims to understand which tumour features can help predict this risk and guide future treatment decisions… Read more
- BRAIN UK Ref: 26/009 – Spatial transcriptome mapping of the inflamed muscle microenvironment in rare disease juvenile dermatomyositis
Juvenile dermatomyositis (JDM) is a rare disease in children. It causes swelling and damage in the muscles and skin. This leads to weakness, pain, and problems that can last a long time. There are treatments but they don’t work well for every child…Read more - BRAIN UK Ref: 26/008 – Elucidating the mechanisms underpinnning anti-tumour immune responses in brain metastasesOnce cancer has spread to different organs, it is known as metastatic cancer. Cancer that has spread into the brain is known as brain metastases. These most commonly develop in patients with skin, lung and breast cancer and are observed in ~30% of all patients with metastatic cancer… Read more
- BRAIN UK Ref: 26/007 – Single myofiber multi-function omics: deciphering the role of skeletal muscle in MND
Skeletal muscle is a very complicated tissue, responsible for generating all forms of human movement and is very important for maintaining human health across our life-course. It is also one of the major sites of dysfunction in diseases…Read more - BRAIN UK Ref: 26/006 – A UK multicentre analysis of real world meningioma cohorts: methylation and risk score analysis, management and clinical outcomesWhen people are diagnosed with meningioma, which is a type of brain tumour, samples from their tumours are sent to a specialised laboratory in London. This lab receives samples from hospitals across the UK… Read more
- BRAIN UK Ref: 26/005 – Paediatric brain tumour, stromal, and immune cell responses to radiation therapyRadiotherapy to the brain, often used to treat cancer, can lead to long-term problems with memory and thinking. One possible cause is inflammation in the brain, but how this develops over time is not well understood. Read more
- BRAIN UK Ref: 26/004 – Investigation of mitochondrial dysfunction in Inclusion Body MyositisInclusion body myositis (IBM) is a slowly progressive muscle disease in adults over the age of 50. It causes increasing weakness in the thigh muscles and the muscles that bend the fingers, making everyday activities such as walking, climbing stairs, and swallowing progressively difficult…Read more
- BRAIN UK Ref: 26/002 – Spatiotemporal Alterations in Aquaporin-4 Localisation and Oedema-Associated Neuropathology after Traumatic Brain Injury
Traumatic brain injury (TBI) is a leading global health concern. The initial insult, known as primary injury, causes alterations in the brain called secondary injury. Brain swelling is a critical secondary injury response that detrimentally… Read more - BRAIN UK Ref: 26/001 – Expression of Galectin 3 in recurrent glioblastomaGlioblastoma is a type of brain cancer that’s very difficult to treat. Current treatments – surgery to remove the tumour, chemotherapy, and radiation – help but don’t cure the disease…Read more