Skeletal muscle is a very complicated tissue, responsible for generating all forms of human movement and is very important for maintaining human health across our life-course. It is also one of the major sites of dysfunction in diseases…Read more

Radiotherapy to the brain, often used to treat cancer, can lead to long-term problems with memory and thinking. One possible cause is inflammation in the brain, but how this develops over time is not well understood. Read more

Inclusion body myositis (IBM) is a slowly progressive muscle disease in adults over the age of 50. It causes increasing weakness in the thigh muscles and the muscles that bend the fingers, making everyday activities such as walking, climbing stairs, and swallowing progressively difficult…Read more

Traumatic brain injury (TBI) is a leading global health concern. The initial insult, known as primary injury, causes alterations in the brain called secondary injury. Brain swelling is a critical secondary injury response that detrimentally… Read more

Glioblastoma is a type of brain cancer that’s very difficult to treat. Current treatments – surgery to remove the tumour, chemotherapy, and radiation – help but don’t cure the disease…Read more

Alzheimer’s disease is the most common cause of dementia worldwide. It happens when two abnormal proteins (called amyloid and tau) build up in the brain and damage… Read more

Babies born too early (preterm), especially before 28 weeks of pregnancy, are at risk of facing… Read more

Rasmussen Encephalitis (RE) is a rare and devastating brain disease affecting children, leading to uncontrollable seizures, one-sided paralysis, and loss of speech or learning ability…Read more

We’re looking at why some people get genetic diseases that affect their nerves and muscles. We’re focusing on tiny parts of cells called… Read more

Paediatric diffuse midline glioma (DMG) is one of the most aggressive childhood brain cancers, characterised by a mutation called H3K27M. These tumours grow in the… Read more