Emotional and motivational disorders, such as drug addiction, anxiety, and depression, affect millions of people worldwide. These conditions can make daily life very difficult and often come with high relapse rates… Read more

Using tissue from BRAIN UK we have already demonstrated that a novel enzyme named LOX is under expressed in the supporting cells in bipolar disorder. We now wish to expand upon these findings… Read more

1% of the population suffers from schizophrenia suffering immensely distressing symptoms. The illness emerges in early adulthood, leading to a severe impact on society both economically (£12bn a year in UK) and socially… Read more

Lysyl Oxidase (LOX) is an extracellular enzyme that is important for the formation and maintenance of the extracellular matrix (ECM). Disruption of Lox expression and/or activity results in fibrosis… Read more

We are interested to understand whether there is a genetic basis for susceptibility to Wernicke Korsakoff’s Syndrome (WKS). This syndrome has a number of symptoms including short-term memory loss and in extreme cases psychosis… Read more

The microscopic pathological examination of brain tissue in psychiatric disorders such as schizophrenia, depression and bipolar disorders has historically been difficult to interpret… Read more

Schizophrenia is a disorder affecting normal cognition resulting in a breakdown of coherent thought and speech processes and social and behavioural dysfunction… Read more