Some people have problems with their nerves that cause pain, weakness, numbness or tingling in their arms or legs. These problems are called inflammatory neuropathies… Read more

Juvenile dermatomyositis (JDM) is a rare autoimmune condition in which the body’s defence system (designed to stop infections) attacks muscles and skin leading to muscle weakness and skin rashes… Read more

Immunotherapies are anti-cancer drugs that activate the patient’s immune system. This makes it more effective at killing cancer cells. However, the immune system can sometimes attack normal organs… Read more

Cholesterol is essential to the maintenance and function of the nerve cells. It is delivered to the cells via particles called lipoprotein. The space that the particles have to go through is a narrow cleft between… Read more

A new treatment for Alzheimer’s disease has recently been approved in the United States (Aduhelm). However, there is a problem with a side effect… Read more

Symptoms and behaviour change, such as depressed mood, fatigue, social withdrawal, increased pain sensitivity and cognitive impairment, are important due to the burden of disease they impose… Read more

COVID-19 is a disease caused by a virus called SARS-CoV-2 which was first reported in China at the end of 2019, but soon after the virus spread across the world causing a pandemic… Read more

Macrophages are cells which form a crucial role in the integrity of the normal immune system but also in the generation of inflammatory diseases. We wish to study what role these cells have… Read more

Neonatal Hypoxic Ischaemic Encephalopathy (HIE) is a significant worldwide problem that affects 1.3 to 1.7 per 1000 live births in UK. It occurs in babies who have been starved of oxygen around the time of birth… Read more

Neurolupus is a serious brain disease which affects most patients who suffer from the autoimmune disease systemic lupus erythematosus (SLE). It can be very disabling, the cause is not known and treatment options are limited… Read more

A brain tumour can be defined as a mass lesion that is composed mostly of abnormal cells that grow in the brain. The cells can come from the brain itself or from its coverings… Read more

When we have an infection we feel sick and uninterested in things. This is known as “sickness behaviour” and is transitory. Studies have shown that this occurs because certain brain cells… Read more

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Autoimmune encephalitis is a relatively uncommon disorder typically associated with an underlying cancer. A number of sub-types have been described associated with molecules called antibodies directing inappropriate… Read more

Particular cell types in the central nervous system called mast cells and basophils are involved in the normal immune response to inflammation… Read more

Schizophrenia is a disorder affecting normal cognition resulting in a breakdown of coherent thought and speech processes and social and behavioural dysfunction… Read more

A particular cell type in the central nervous system called microglia are involved in the normal immune response to inflammation caused by processes such as infection, traumatic injury and inflammatory diseases… Read more

Neuromyelitis optica (NMO, Devic’s disease) is an autoimmune inflammatory disorder of the central nervous system which results in the loss of the conducting sheath of nerve fibres… Read more