Dravet syndrome is a severe form of epilepsy. It is characterized by frequent, prolonged seizures. These are often triggered by high body temperature (hyperthermia), developmental delay, speech impairment, ataxia, sleep disturbances, and… Read more

Alpers’ syndrome is a rare mitochondrial disease caused by changes in a gene known as POLG1 which results in very severe childhood epilepsy with rapid neurological decline and premature death… Read more

Microglia are the immune cells of the brain. They play an important role in defending the brain against injury and infection. However, it has become apparent that these cells are… Read more

Spinal muscular atrophy (SMA) is a childhood form of motor neurone disease. It targets the nerve cells (motor neurons) found in the spinal cord. These nerve cells are the key link between the brain… Read more

he neocortex (the outer part of the brain) is the seat of many of the higher cognitive functions that make us human, such as our memory, speech and advanced learning. How the neocortex controls these functions remains… Read more

Alpers’ syndrome is a rare progressive disorder which typically affects young children (6 months to 3 years) and is characterised by severe epilepsy, loss of developmental skills and liver failure… Read more

Alexander’s disease is a rare terminal disease mostly affecting children. The disease is in a group of brain cells called astrocytes and a genetic link has been identified as the cause. However, little is known about… Read more

The cerebral cortex is the major centre for cognitive processes, including memory, awareness and language, and is arguably an integral part of what makes us human. Understanding the mechanisms behind its development and function… Read more

Spinal muscular atrophy (SMA) is severely debilitating and ultimately life-limiting conditions that selectively affect motor neurons, the nerve cells that control our voluntary muscles… Read more

Our research centres on finding out more about how brain damage develops in babies with cerebral palsy and investigating the natural processes that are involved in brain repair… Read more

A hugely varying range of impairments and abilities are associated with normal and abnormal development of our brain. Autism spectrum disorder (ASD) in its most severe form can be very disabling… Read more

Alpers’ syndrome is a rare progressive disease typically of childhood characterized by seizures, mental retardation, blindness and liver failure. It is caused by a defect in a gene present in subcellular elements called mitochondria… Read more

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