
Demyelination lay summaries
- BRAIN UK Ref: 24/005 – Leveraging Human Cell Atlas technologies to shed light on the immune aetiology of chronic inflammatory demyelinating polyradiculoneuropathyChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare neurological condition characterised by inflammation of the patient’s peripheral nerves… Read more
- BRAIN UK Ref: 23/009 – SPCA in ALSThis project will develop a new treatment for amyotrophic lateral sclerosis (ALS)/motor neuron disease, addressing the dysfunction of a small part inside the nerve cell… Read more
- BRAIN UK Ref: 22/007 – Alpha-synuclein pathology in metachromatic leukodystrophyMetachromatic leukodystrophy (MLD) is a rare genetic disease that normally affects children and leads to damage to the brain and premature death. In contrast, Parkinson’s disease (PD) is a relatively common disease that affects older… Read more
- BRAIN UK Ref: 21/009 – Alpha-synuclein in Krabbe diseaseKrabbe disease is a rare disease that affects very young infants and usually causes their death by the age of two years old. Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease, and… Read more
- BRAIN UK Ref: 20/004 – Ultrastructural Endoneurial Pathology to Explain the Normal Function of the Human Blood Nerve Barrier and the Pathogenesis of Inflammatory Nerve DiseasePeripheral nerves (PN) communicate information to the brain from surface tissues and back to muscles to make responses. Peripheral neuropathies are conditions in which those nerves can become damaged… Read more
- BRAIN UK Ref: 20/003 – Cellular and genetic pathomechanisms of central pontine myelinolysisCentral pontine myelinolysis (CPM) and Alexander’s diseases (AxD) are rare neurological disorders with similar symptoms. One of these symptoms is the loss of special coating on nerve cells called myelin… Read more
- BRAIN UK Ref: 16/010 – Selective vulnerability in MND/FTDMotor neuron disease (MND) is a progressive neurodegenerative disorder that destroys motor neurons, the cells that carry the signal for muscle movement such as speaking, walking, breathing, and swallowing. There are different types… Read more
- BRAIN UK Ref: 11/001 – Role of neutrophils in the pathogenesis of neuromyelitis opticaNeuromyelitis optica (NMO, Devic’s disease) is an autoimmune inflammatory disorder of the central nervous system which results in the loss of the conducting sheath of nerve fibres… Read more