A new treatment for Alzheimer’s disease has recently been approved in the United States (Aduhelm). However, there is a problem with a side effect… Read more

The West London NHS Trust has provided 240 cases of fixed brain tissue from the Corsellis Collection, a historic collection dating from 1950’s to the 1990’s which has now been disbanded. Newcastle will use the tissue to quantify… Read more

Stroke is the leading cause of long-term disability and the second most common cause of death. In about 20% of cases stroke is caused by changes in small brain vessels… Read more

Bleeding into the brain (a brain haemorrhage) happens in 10 to 15% of all strokes. It is also called ICH (intracerebral haemorrhage). When this happens the chances of dying or being disabled are much higher… Read more

A proportion of strokes with bleeding into the brain (so-called haemorrhages or haematomas) are caused by the deposition of an aggregated protein called amyloid-beta in the walls of the blood vessels, which makes them brittle, and… Read more

The build-up of waste products like amyloid plaques, which are protein pieces, in the walls of arteries is a common cause of stroke and is also commonly observed in Alzheimer’s disease… Read more

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The basement membranes of capillaries and arteries (BM) are the route for the perivascular elimination of amyloid-β, the failure of which is believed to contribute to Alzheimer’s disease (AD) pathogenesis… Read more

Research has implicated the basement membrane (BM) in the route for the perivascular elimination of amyloid-β, the failure of which is believed to contribute to Alzheimer’s disease (AD) pathogenesis… Read more

Alzheimer’s disease is an age related neurodegenerative disorder which affects approximately 24%-33% of the Western population aged 85 and above. Symptoms include profound cognitive decline and memory loss, which can often… Read more

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Subarachnoid haemorrhage (SAH) is bleeding around the brain typically caused by a ruptured blood vessel. A delay in the lack of blood perfusion (ischaemia) is an important determinant in the outcome of SAH… Read more

Injury to the central nervous system through stroke and head injury is common and associated with variable degrees of functional recovery amongst survivors. Tissue damage is mediated by both ischaemia… Read more