
Recently approved lay summaries
- BRAIN UK Ref: 26/001 – Expression of Galectin 3 in recurrent glioblastoma
Glioblastoma is a type of brain cancer that’s very difficult to treat. Current treatments – surgery to remove the tumour, chemotherapy, and radiation – help but don’t cure the disease…Read more - BRAIN UK Ref: 25/022 – Characterising neuroimmune cell profiles in the earliest stages of Alzheimer’s disease using ex vivo brain tissue
Alzheimer’s disease is the most common cause of dementia worldwide. It happens when two abnormal proteins (called amyloid and tau) build up in the brain and damage… Read more - BRAIN UK Ref: 25/021 – Advancing knowledge of brain development: The key to understanding brain injury mechanisms in preterm infants
Babies born too early (preterm), especially before 28 weeks of pregnancy, are at risk of facing… Read more - BRAIN UK Ref: 25/019 – Multimodal approach to investigate pathomechanisms and biomarkers for early diagnosis of Rasmussen Encephalitis (RE)
Rasmussen Encephalitis (RE) is a rare and devastating brain disease affecting children, leading to uncontrollable seizures, one-sided paralysis, and loss of speech or learning ability…Read more - BRAIN UK Ref: 25/018 – Analysing mtDNA large scale rearrangements in patient and control muscle tissue (a substudy of the International Centre for Genomic Medicine in Neuromuscular Disease)
We’re looking at why some people get genetic diseases that affect their nerves and muscles. We’re focusing on tiny parts of cells called… Read more - BRAIN UK Ref: 25/017 -Examining immune-tumour interactions in diffuse midline glioma
Paediatric diffuse midline glioma (DMG) is one of the most aggressive childhood brain cancers, characterised by a mutation called H3K27M. These tumours grow in the… Read more - BRAIN UK Ref: 25/015 – Investigating inflammatory pathways in mitochondrial disease
Mitochondrial diseases are rare disorders that affect the energy-generating “batteries” of the cell. Patients may suffer from cognitive decline, movement disorder, seizures. There are no therapies for mitochondrial diseases. Read more - Brain UK Ref: 25/014 – Identifying patient prognostic biomarkers of glioma connectivity
Gliomas, like glioblastoma (GBM) and diffuse midline glioma (DMG), are common yet aggressive brain tumours with no effective cure. Recent research has shown… Read more - BRAIN UK Ref: 25/013 – Do AN1792 trial patients still show ASC positive cores of former Abeta plaques?
Alzheimer’s disease (AD) is the most common form of dementia, mainly affecting older people. As people in Western countries live longer, more AD cases are… Read more - BRAIN UK Ref: 25/012 – Understanding the role of the extracellular matrix in ependymoma
Cancer in children is caused by cells growing out of control. These cancer cells grow faster than normal cells, invade nearby tissues, and sometimes enter blood vessels. Read more
