Alzheimer’s disease (AD) is characterised by the accumulation of plaques (amyloid-β) in the brain. In recent years several clinical trials have used vaccination approaches… Read more

The build-up of amyloid-β (Aβ) protein in the brain creates plaques, a major sign of Alzheimer’s disease (AD). This protein can also gather in blood vessel walls, causing… Read more

Our research will investigate the relationship between bacterial infection in the brain and Alzheimer’s disease associated with Down syndrome. More specifically, the research will focus on a bacterium that leads to… Read more

Alzheimer’s disease is the commonest cause of dementia in later life, responsible for two thirds of cases. It affects about 5% of people over 65 years of age, 20% of people over the age of 80 and 50% of people over… Read more

A new treatment for Alzheimer’s disease which involves immunotherapy against a protein that accumulates in the brain (Aβ) has recently been approved in the United States (Aduhelm). However, a side effect called… Read more

Alzheimer’s disease is the commonest cause of dementia in later life, responsible for two thirds of cases. It affects about 5% of people over 65 years of age, 20% of people over the age of 80 and 50% of people over 90 years… Read more

Cholesterol is essential to the maintenance and function of the nerve cells. It is delivered to the cells via particles called lipoprotein. The space that the particles have to go through is a narrow cleft between… Read more

A new treatment for Alzheimer’s disease has recently been approved in the United States (Aduhelm). However, there is a problem with a side effect… Read more

As of today, there is no cure for Alzheimer´s disease, the most common cause of dementia. There is an urgent need to explore new avenues in order to find effective treatments. Here, we propose to study the influence of… Read more

Patients with Alzheimer’s disease that receive experimental treatment often develop abnormalities on brain scans. These abnormalities are known as ARIA, which stands for… Read more

During the development of Alzheimer’s disease, proteins build up in the brain to form structures called ‘plaques’ and ‘tangles’. This leads to the loss of connections between nerve cells, and eventually to the death of nerve cells and loss of… Read more

Alzheimer’s disease is the commonest cause of dementia (failure of mental function with age). In the brain in Alzheimer’s disease there are many different abnormalities, affecting many different proteins. Understanding of how the… Read more

Perhaps the most exciting, recent finding in the genetics of Alzheimer’s disease (AD), has been the identification of rare changes in the TREM2 gene which increase vulnerability to AD. Evidence suggests… Read more

Alzheimer’s disease (AD) is the most common type of dementia. The nerve cells are abnormal in this disease. Clumps of protein called tangles containing tau form inside the nerve cells and correlate with… Read more

Alzheimer’s disease (AD) is the commonest form of dementia, with ageing as the main risk factor. There are currently over 6 million people with dementia in the European Union (EU). The increasingly ageing population makes… Read more

There are certain inherited genetic factors that influence the risk of a person getting Alzheimer’s disease. This tells us that the proteins produced by these genes must be important in this type… Read more

The study of the association of different diseases and how they influence each other has proved a promising venue to elucidate the mechanisms underlying several common conditions… Read more

When we have an infection we feel sick and uninterested in things. This is known as “sickness behaviour” and is transitory. Studies have shown that this occurs because certain brain cells… Read more

Alzheimer’s disease (AD) is the most common cause of dementia in the elderly and is associated with the accumulation of a particular molecule (called tau protein) in the central nervous system. The incidence of AD increases… Read more