Ribogenesis boosts controlled by HEATR1-MYC interplay promote transition into brain tumour growth. Diaz LR, Gil-Ranedo J, Jaworek KJ, Nsek N, Marques JP, Costa E, Hilton DA, Bieluczyk H, Warrington O, Hanemann CO, Futschik ME, Bossing T, Barros CS. EMBO Rep. 2024 Jan;25(1):168-197. doi: 10.1038/s44319-023-00017-1. Epub 2024 Jan 15. PMID: 38225354; PMCID: PMC10897169.

IDHwt glioblastomas can be stratified by their transcriptional response to standard treatment, with implications for targeted therapy. Tanner G, Barrow R, Ajaib S, Al-Jabri M, Ahmed N, Pollock S, Finetti M, Rippaus N, Bruns AF, Syed K, Poulter JA, Matthews L, Hughes T, Wilson E, Johnson C, Varn FS, Brüning-Richardson A, Hogg C, Droop A, Gusnanto A, Care MA, Cutillo L, Westhead DR, Short SC, Jenkinson MD, Brodbelt A, Chakrabarty A, Ismail A, Verhaak RGW, Stead LF. Genome Biol. 2024 Feb 7;25(1):45. doi: 10.1186/s13059-024-03172-3. PMID: 38326875; PMCID: PMC10848526.

Recurrent adamantinomatous craniopharyngiomas show MAPK pathway activation, clonal evolution and rare TP53-loss-mediated malignant progression. Apps JR, Gonzalez-Meljem JM, Guiho R, Pickles JC, Prince E, Schwalbe E, Joshi N, Stone TJ, Ogunbiyi O, Chalker J, Bassey A, Otto G, Davies R, Hughes D, Brandner S, Tan E, Lee V, Hayhurst C, Kline C, Castellano S, Hankinson T, Deutschbein T, Jacques TS, Martinez-Barbera JP. Acta Neuropathol Commun. 2024 Aug 10;12(1):127. doi: 10.1186/s40478-024-01838-4. PMID: 39127699; PMCID: PMC11316312.

Evaluating circulating tumour cell enrichment techniques to establish an appropriate method for clinical application in glioblastomas. Barber HR, Perks CM, Kurian KM. Front Neurol. 2024 Feb 28;15:1358531. doi: 10.3389/fneur.2024.1358531. PMID: 38481938; PMCID: PMC10932969.

Targeting MERTK on tumour cells and macrophages: a potential intervention for sporadic and NF2-related meningioma and schwannoma tumours. Dave F, Herrera K, Lockley A, van de Weijer LL, Henderson S, Sofela AA, Hook L, Adams CL, Ercolano E, Hilton DA, Maze EA, Kurian KM, Ammoun S, Hanemann CO. Oncogene. 2024 Oct;43(41):3049-3061. doi: 10.1038/s41388-024-03131-z. Epub 2024 Aug 23. Erratum in: Oncogene. 2024 Oct;43(41):3080. doi: 10.1038/s41388-024-03177-z. PMID: 39179860; PMCID: PMC11458476

Genomic landscape and actionable mutations of brain metastases derived from non-small cell lung cancer: A systematic review. Andrews LJ, Thornton ZA, Saleh R, Dawson S, Short SC, Daly R, Higgins JPT, Davies P, Kurian KM. Neurooncol Adv. 2023 Nov 24;5(1):vdad145. doi: 10.1093/noajnl/vdad145. PMID: 38130901; PMCID: PMC10734675.

Identification of a putative molecular subtype of adult-type diffuse astrocytoma with recurrent MAPK pathway alterations. Sievers P, Bielle F, Göbel K, Schrimpf D, Nichelli L, Mathon B, Appay R, Boldt HB, Dohmen H, Selignow C, Acker T, Vicha A, Martinetto H, Schweizer L, Schüller U, Brandner S, Wesseling P, Schmid S, Capper D, Abdullaev Z, Aldape K, Korshunov A, Krieg SM, Wick W, Pfister SM, von Deimling A, Reuss DE, Jones DTW, Sahm F. Acta Neuropathol. 2024 Jul 18;148(1):7. doi: 10.1007/s00401-024-02766-2. PMID: 39026106; PMCID: PMC11258072.

Oncogenic extrachromosomal DNA identification using whole-genome sequencing from formalin-fixed glioblastomas. Noorani I, Luebeck J, Rowan A, Grönroos E, Barbe V, Fabian M, Nicoll JAR, Boche D, Bafna V, Mischel PS, Swanton C. Ann Oncol. 2024 Jun;35(6):570-573. doi: 10.1016/j.annonc.2024.03.008. Epub 2024 Mar 28. PMID: 38555024.

Large language models as a diagnostic support tool in neuropathology. Hewitt KJ, Wiest IC, Carrero ZI, Bejan L, Millner TO, Brandner S, Kather JN. J Pathol Clin Res. 2024 Nov;10(6):e70009. doi: 10.1002/2056-4538.70009. PMID: 39505569; PMCID: PMC11540532.

Carbon dot-based fluorescent antibody nanoprobes as brain tumour glioblastoma diagnostics. Ghirardello M, Shyam R, Liu X, Garcia-Millan T, Sittel I, Ramos-Soriano J, Kurian KM, Galan MC. Nanoscale Adv. 2022 Mar 3;4(7):1770-1778. doi: 10.1039/d2na00060a. PMID: 35434521; PMCID: PMC8962998.

Delineating selective vulnerability of inhibitory interneurons in Alpers’ syndrome. Smith LA, Erskine D, Blain A, Taylor RW, McFarland R, Lax NZ. Neuropathol Appl Neurobiol. 2022 Oct;48(6):e12833. doi: 10.1111/nan.12833. Epub 2022 Jul 19. PMID: 35790454; PMCID: PMC9546160.

A reassessment of spinal cord pathology in severe infantile spinal muscular atrophy: Reassessment of spinal cord pathology. Allardyce H, Lawrence BD, Crawford TO, Sumner CJ, Parson SH. Neuropathol Appl Neurobiol. 2024 Oct;50(5):e13013. doi: 10.1111/nan.13013. PMID: 39449271.

Insulin-like growth factor binding protein-2 and glucose-regulated protein 78 kDa: Potential biomarkers affect prognosis in IDH-wildtype glioblastoma patients. Harland AJ, Perks CM, White P, Kurian KM, Barber HR. Cancer Med. 2023 Jul;12(13):14426-14439. doi: 10.1002/cam4.6071. Epub 2023 May 22. PMID: 37212470; PMCID: PMC10358216

Role of DNA methylation in the relationship between glioma risk factors and glioma incidence: a two-step Mendelian randomization study. Howell AE, Relton C, Martin RM, Zheng J, Kurian KM. Sci Rep. 2023 Apr 21;13(1):6590. doi: 10.1038/s41598-023-33621-1. PMID: 37085538; PMCID: PMC10121678.

Pre-diagnostic blood biomarkers for adult glioma. Andrews LJ, Davies P, Herbert C, Kurian KM. Front Oncol. 2023 May 17;13:1163289. doi: 10.3389/fonc.2023.1163289. PMID: 37265788; PMCID: PMC10229864.

Refining the Intraoperative Identification of Suspected High-Grade Glioma Using a Surgical Fluorescence Biomarker: GALA BIDD Study Report. Watts C, Dayimu A, Matys T, Ashkan K, Price S, Jenkinson MD, Doughton G, Mather C, Young G, Qian W, Kurian KM. J Pers Med. 2023 Mar 13;13(3):514. doi: 10.3390/jpm13030514. PMID: 36983696; PMCID: PMC10058333.

DNA methylation-based classification of glioneuronal tumours synergises with histology and radiology to refine accurate molecular stratification. Stone TJ, Mankad K, Tan AP, Jan W, Pickles JC, Gogou M, Chalker J, Slodkowska I, Pang E, Kristiansen M, Madhan GK, Forrest L, Hughes D, Koutroumanidou E, Mistry T, Ogunbiyi O, Ahmed SW, Cross JH, Hubank M, Hargrave D, Jacques TS. Neuropathol Appl Neurobiol. 2023 Apr;49(2):e12894. doi: 10.1111/nan.12894. PMID: 36843390.

Clinical impact of anti-inflammatory microglia and macrophage phenotypes at glioblastoma margins. Noorani I, Sidlauskas K, Pellow S, Savage R, Norman JL, Chatelet DS, Fabian M, Grundy P, Ching J, Nicoll JAR, Boche D. Brain Commun. 2023 Jun 2;5(3):fcad176. doi: 10.1093/braincomms/fcad176. PMID: 37324244; PMCID: PMC10265726.

Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas. Wang JZ, Patil V, Liu J, Dogan H, Tabatabai G, Yefet LS, Behling F, Hoffman E, Bunda S, Yakubov R, Kaloti R, Brandner S, Gao A, Cohen-Gadol A, Barnholtz-Sloan J, Skardelly M, Tatagiba M, Raleigh DR, Sahm F, Boutros PC, Aldape K; International Consortium on Meningiomas (ICOM); Nassiri F, Zadeh G. Acta Neuropathol. 2023 Jul;146(1):145-162. doi: 10.1007/s00401-023-02571-3. Epub 2023 Apr 24. Erratum in: Acta Neuropathol. 2023 May 12;: PMID: 37093270; PMCID: PMC10261216.

Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions. Bogumil H, Sill M, Schrimpf D, Ismer B, Blume C, Rahmanzade R, Hinz F, Cherkezov A, Banan R, Friedel D, Reuss DE, Selt F, Ecker J, Milde T, Pajtler KW, Schittenhelm J, Hench J, Frank S, Boldt HB, Kristensen BW, Scheie D, Melchior LC, Olesen V, Sehested A, Boué DR, Abdullaev Z, Satgunaseelan L, Kurth I, Seidlitz A, White CL, Ng HK, Shi ZF, Haberler C, Deckert M, Timmer M, Goldbrunner R, Tauziède-Espariat A, Varlet P, Brandner S, Alexandrescu S, Snuderl M, Aldape K, Korshunov A, Witt O, Herold-Mende C, Unterberg A, Wick W, Pfister SM, von Deimling A, Jones DTW, Sahm F, Sievers P. Acta Neuropathol. 2023 May;145(5):667-680. doi: 10.1007/s00401-023-02558-0. Epub 2023 Mar 18. PMID: 36933012; PMCID: PMC10119244.

Molecular diagnostic tools for the World Health Organization (WHO) 2021 classification of gliomas, glioneuronal and neuronal tumors; an EANO guideline. Sahm F, Brandner S, Bertero L, Capper D, French PJ, Figarella-Branger D, Giangaspero F, Haberler C, Hegi ME, Kristensen BW, Kurian KM, Preusser M, Tops BBJ, van den Bent M, Wick W, Reifenberger G, Wesseling P. Neuro Oncol. 2023 Oct 3;25(10):1731-1749. doi: 10.1093/neuonc/noad100. PMID: 37279174; PMCID: PMC10547522.

Direct image to subtype prediction for brain tumors using deep learning. Hewitt KJ, Löffler CML, Muti HS, Berghoff AS, Eisenlöffel C, van Treeck M, Carrero ZI, El Nahhas OSM, Veldhuizen GP, Weil S, Saldanha OL, Bejan L, Millner TO, Brandner S, Brückmann S, Kather JN. Neurooncol Adv. 2023 Nov 1;5(1):vdad139. doi: 10.1093/noajnl/vdad139. PMID: 38106649; PMCID: PMC10724115.

Multicolor Photoluminescent Carbon Dots à La Carte for Biomedical Applications. Garcia-Millan T, Ramos-Soriano J, Ghirardello M, Liu X, Santi CM, Eloi JC, Pridmore N, Harniman RL, Morgan DJ, Hughes S, Davis SA, Oliver TAA, Kurian KM, Galan MC. ACS Appl Mater Interfaces. 2023 Sep 27;15(38):44711-44721. doi: 10.1021/acsami.3c08200. Epub 2023 Sep 16. PMID: 37715711; PMCID: PMC10540137.

Histological examination of choroid plexus epithelia changes in schizophrenia. Williams MR, Macdonald CM, Turkheimer FE. Brain Behav Immun. 2023 Jul;111:292-297. doi: 10.1016/j.bbi.2023.04.016. Epub 2023 May 5. PMID: 37150267.

Microglial inflammasome activation drives developmental white matter injury. Holloway RK, Ireland G, Sullivan G, Becher JC, Smith C, Boardman JP, Gressens P, Miron VE. Glia. 2021 May;69(5):1268-1280. doi: 10.1002/glia.23963. Epub 2021 Jan 8. PMID: 33417729; PMCID: PMC8607465.

Localized microglia dysregulation impairs central nervous system myelination in development. Holloway RK, Zhang L, Molina-Gonzalez I, Ton K, Nicoll JAR, Boardman JP, Liang Y, Williams A, Miron VE. Acta Neuropathol Commun. 2023 Mar 22;11(1):49. doi: 10.1186/s40478-023-01543-8. PMID: 36949514; PMCID: PMC10035254.

The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI-neuropathology diagnostic accuracy study. Charidimou A, Boulouis G, Frosch MP, Baron JC, Pasi M, Albucher JF, Banerjee G, Barbato C, Bonneville F, Brandner S, Calviere L, Caparros F, Casolla B, Cordonnier C, Delisle MB, Deramecourt V, Dichgans M, Gokcal E, Herms J, Hernandez-Guillamon M, Jäger HR, Jaunmuktane Z, Linn J, Martinez-Ramirez S, Martínez-Sáez E, Mawrin C, Montaner J, Moulin S, Olivot JM, Piazza F, Puy L, Raposo N, Rodrigues MA, Roeber S, Romero JR, Samarasekera N, Schneider JA, Schreiber S, Schreiber F, Schwall C, Smith C, Szalardy L, Varlet P, Viguier A, Wardlaw JM, Warren A, Wollenweber FA, Zedde M, van Buchem MA, Gurol ME, Viswanathan A, Al-Shahi Salman R, Smith EE, Werring DJ, Greenberg SM. Lancet Neurol. 2022 Aug;21(8):714-725. doi: 10.1016/S1474-4422(22)00208-3. PMID: 35841910; PMCID: PMC9389452.

Iatrogenic cerebral amyloid angiopathy: an emerging clinical phenomenon. Banerjee G, Samra K, Adams ME, Jaunmuktane Z, Parry-Jones AR, Grieve J, Toma AK, Farmer SF, Sylvester R, Houlden H, Rudge P, Mead S, Brandner S, Schott JM, Collinge J, Werring DJ. J Neurol Neurosurg Psychiatry. 2022 May 16:jnnp-2022-328792. doi: 10.1136/jnnp-2022-328792. Epub ahead of print. PMID: 35577510.

Microglial contribution to the pathology of neurodevelopmental disorders in humans. Matuleviciute R, Akinluyi ET, Muntslag TAO, Dewing JM, Long KR, Vernon AC, Tremblay ME, Menassa DA. Acta Neuropathol. 2023 Sep 1. doi: 10.1007/s00401-023-02629-2. Epub ahead of print. PMID: 37656188.

Cerebellar ataxia, neuropathy, vestibular areflexia syndrome due to RFC1 repeat expansion. Cortese A, Tozza S, Yau WY, Rossi S, Beecroft SJ, Jaunmuktane Z, Dyer Z, Ravenscroft G, Lamont PJ, Mossman S, Chancellor A, Maisonobe T, Pereon Y, Cauquil C, Colnaghi S, Mallucci G, Curro R, Tomaselli PJ, Thomas-Black G, Sullivan R, Efthymiou S, Rossor AM, Laurá M, Pipis M, Horga A, Polke J, Kaski D, Horvath R, Chinnery PF, Marques W, Tassorelli C, Devigili G, Leonardis L, Wood NW, Bronstein A, Giunti P, Züchner S, Stojkovic T, Laing N, Roxburgh RH, Houlden H, Reilly MM. Brain. 2020 Feb 1;143(2):480-490. doi: 10.1093/brain/awz418. PMID: 32040566; PMCID: PMC7009469.

Increased uptake of the P2X7 receptor radiotracer 18 F-JNJ-64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice. Morgan J, Moreno O, Alves M, Baz Z, Menéndez Méndez A, Leister H, Melia C, Smith J, Visekruna A, Nicke A, Bhattacharya A, Ceusters M, Henshall DC, Gómez-Vallejo V, Llop J, Engel T. Epilepsia. 2023 Feb;64(2):511-523. doi: 10.1111/epi.17484. Epub 2022 Dec 27. PMID: 36507708; PMCID: PMC10108015.